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MAP kinase genes and colon and rectal cancer.
Slattery ML, Lundgreen A, Wolff RK. Slattery ML, et al. Carcinogenesis. 2012 Dec;33(12):2398-408. doi: 10.1093/carcin/bgs305. Epub 2012 Oct 1. Carcinogenesis. 2012. PMID: 23027623 Free PMC article.
We evaluate genetic variation in the c-Jun-N-terminal kinases, p38, and extracellular regulated kinases 1/2 MAPK-signaling pathways and colon and rectal cancer risk using data from population-based case-control studies (colon: n = 1555 cases, 1956 controls; rectal: n = 754 cases, …
We evaluate genetic variation in the c-Jun-N-terminal kinases, p38, and extracellular regulated kinases 1/2 MAPK-signaling pathways and colo …
Nicotine-derived NNK induces the stemness enrichment of CRC cells through regulating the balance of DUSP4-ERK1/2 feedback loop.
Chen Y, Wang Q, Cao L, Tang Y, Yao M, Bi H, Huang Y, Sun G, Song J. Chen Y, et al. Ecotoxicol Environ Saf. 2021 May;214:112057. doi: 10.1016/j.ecoenv.2021.112057. Epub 2021 Mar 2. Ecotoxicol Environ Saf. 2021. PMID: 33662786 Free article.
In mechanism, we found that NNK-activated ERK1/2 played an important role in enrichment of CRC stem cells and the up-regulation of DUSP4, a major negative regulator of ERK1/2. Moreover, DUSP4 up-regulation was essential for maintaining NNK-activated ERK1/2 in an app …
In mechanism, we found that NNK-activated ERK1/2 played an important role in enrichment of CRC stem cells and the up-regulation of DUSP4 …
Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner.
Yin R, Eger G, Sarri N, Rorsman C, Heldin CH, Lennartsson J. Yin R, et al. Biochem Biophys Res Commun. 2019 Nov 12;519(3):469-474. doi: 10.1016/j.bbrc.2019.09.014. Epub 2019 Sep 13. Biochem Biophys Res Commun. 2019. PMID: 31526568
Dual specificity phosphatase (DUSP) 4 has been described as a negative regulator of MAP kinase signaling, in particular for the ERK1/2 and JNK pathways. We found that DUSP4 expression was upregulated in response to prolonged platelet-derived growth factor (PDGF)-BB stimula …
Dual specificity phosphatase (DUSP) 4 has been described as a negative regulator of MAP kinase signaling, in particular for the ERK1/2 and J …